Coleus forskohlii has a rich diversity of ethnopharmacological applications including weight management, heart ailments, and hypotension. Coleus is known to be used as a condiment in some parts of India. Forskolin and its derivatives inhibit platelet aggregation, mast cell degranulation, relaxes arteries, regulates insulin secretion and thyroid function, decrease adipose accumulation, reduce body weight and stimulates digestive enzymes secretion. It is used in skin care, treatment of cardiovascular and respiratory diseases, etc.
Potential candidate for topical administration in sunless tanning products and UV protection.
Coleus forskohlii is a perennial herb in a large genus of mints. It is an important traditional Ayurvedic herb that has been a part of Indian medicine for centuries. Coleus is the source of a unique substance known as FORSKOLIN.
The topical application of forskolin to a murine model with humanized skin and a mutant MC1R, has resulted in significant melanization. This study implied that forskolin is a potential candidate for clinical application in sunless tanning products as well as a topical small-molecule manipulation of pigmentation that would protect against UV-induced cutaneous DNA damage.
A Revolution in Weight Management
Forskolin directly, rapidly and reversibly activate adenylate cyclase, resulting in a remarkable increase in the intracellular cAMP level. cAMP increases the utilization of body fat, basal metabolic rate, and regulates the body’s thermogenic response to food. Thus, the forskolin supplement may lead to fat loss without muscle mass loss.
A topical cosmetic slimming product combining forskolin, tetrahydroxypropyl ethylenediamine, caffeine, carnitine, and retinol have been developed. Clinical trial on five selected parts of the body was conducted among 78 women. The formulation improved skin feature and significantly reduced fat in the circumference of abdomen, hips-buttocks, and waist